Structure of PDB 6w9k Chain A Binding Site BS01

Receptor Information
>6w9k Chain A (length=249) Species: 32630 (synthetic construct) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEM
VGGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQK
Ligand information
Receptor-Ligand Complex Structure
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PDB6w9k Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		V44 K48 M62 M221 E224
Binding residue
(residue number reindexed from 1)		V47 K51 M65 M224 E227
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6w9k, PDBe:6w9k, PDBj:6w9k
PDBsum6w9k
PubMed32917814
UniProtA0A1X8XLE9

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