Structure of PDB 6twn Chain A Binding Site BS01

Receptor Information

>6twn Chain A (length=306) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PFTKHGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVL
GEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPN
SQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTS
ALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEE
NRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISA
KTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRD
KAPGQL

Ligand information

>6twn Chain D (length=17) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DSEIDQLFRIFRALGTP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6twn Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
Resolution	2.28 Å
Binding residue (original residue number in PDB)	L1492 A1495 T1496 A1499 K1500 S1503 K1544
Binding residue (residue number reindexed from 1)	L139 A142 T143 A146 K147 S150 K191

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003779	actin binding

View graph for
Molecular Function

External links

PDB	RCSB:6twn, PDBe:6twn, PDBj:6twn
PDBsum	6twn
PubMed	34118235
UniProt	P26039\|TLN1_MOUSE Talin-1 (Gene Name=Tln1)

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