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BioLiP

Structure of PDB 6twn Chain A Binding Site BS01

Receptor Information
>6twn Chain A (length=306) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFTKHGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVL
GEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPN
SQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTS
ALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEE
NRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISA
KTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRD
KAPGQL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6twn Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		L1492 A1495 T1496 A1499 K1500 S1503 K1544
Binding residue
(residue number reindexed from 1)		L139 A142 T143 A146 K147 S150 K191
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6twn, PDBe:6twn, PDBj:6twn
PDBsum6twn
PubMed34118235
UniProtP26039|TLN1_MOUSE Talin-1 (Gene Name=Tln1)

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