Structure of PDB 6roz Chain A Binding Site BS01
Receptor Information
>6roz Chain A (length=102) Species:
9606
(Homo sapiens) [
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SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NC
Ligand information
>6roz Chain B (length=10) Species:
32630
(synthetic construct) [
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QTEYATIVFP
Receptor-Ligand Complex Structure
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PDB
6roz
Molecular mechanism of SHP2 activation by PD-1 stimulation.
Resolution
2.89 Å
Binding residue
(original residue number in PDB)
R32 S34 K35 S36 T42 H53 G67 G68 K89 E90 K91
Binding residue
(residue number reindexed from 1)
R30 S32 K33 S34 T40 H51 G65 G66 K87 E88 K89
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
External links
PDB
RCSB:6roz
,
PDBe:6roz
,
PDBj:6roz
PDBsum
6roz
PubMed
32064351
UniProt
Q06124
|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)
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