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Structure of PDB 6roz Chain A Binding Site BS01

Receptor Information

>6roz Chain A (length=102) Species: 9606 (Homo sapiens)

SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NC

Ligand information

>6roz Chain B (length=10) Species: 32630 (synthetic construct)

QTEYATIVFP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6roz Molecular mechanism of SHP2 activation by PD-1 stimulation.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): R32 S34 K35 S36 T42 H53 G67 G68 K89 E90 K91
• Binding residue (residue number reindexed from 1): R30 S32 K33 S34 T40 H51 G65 G66 K87 E88 K89

Enzymatic activity

• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

External links

• PDB: RCSB:6roz, PDBe:6roz, PDBj:6roz
• PDBsum: 6roz
• PubMed: 32064351
• UniProt: Q06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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