Structure of PDB 6erf Chain A Binding Site BS01

Receptor Information
>6erf Chain A (length=493) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLA
VVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDM
MGHGSDYSLSEVLWVCANLFSDSHKRIMLFTNEDNPHGNDSAKASRARTK
AGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKL
EDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLY
RETNEPVKTKTRTFNTSTGLPSDTKRSQIYGSRQIILEKEETEELKRFDD
PGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEK
EVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADD
KRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEA
LALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYN
Ligand information
Receptor-Ligand Complex Structure
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PDB6erf XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		S257 T300
Binding residue
(residue number reindexed from 1)		S218 T261
Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6erf, PDBe:6erf, PDBj:6erf
PDBsum6erf
PubMed30291363
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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