Structure of PDB 5zk9 Chain A Binding Site BS01

Receptor Information
>5zk9 Chain A (length=183) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQ
LSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFW
LETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKTKNRFVV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zk9 Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		H37 P38 Q40 V69 W73 E132 L135 G139 E140 D147
Binding residue
(residue number reindexed from 1)		H7 P8 Q10 V39 W43 E102 L105 G109 E110 D117
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:5zk9, PDBe:5zk9, PDBj:5zk9
PDBsum5zk9
PubMed30881679
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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