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Structure of PDB 5wfc Chain A Binding Site BS01

Receptor Information
>5wfc Chain A (length=460) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEWELPRLRTSFIFQDDYKSQDLAEFFDVKFYPYSPPGAPPVFAATSKKH
AVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIA
GNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIR
IWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW
ALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDT
IVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFTPSRPAMFTRLAQFH
TPDCGVQFFMRFRMYHVPGKHPILAFANAKSKTFFWDLARFGEYARFMAD
LKEAQQSYNGRVVVVDQGQGISLAQAQQVHGVVMKPAWLVPGFSRETLQA
WADMYDLSNPVGLIKAHRSLAIDGAFVGRQVGWSPEGEWCVVVGNGNRAL
IYQRWGKERG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wfc An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors.
Resolution2.282 Å
Binding residue
(original residue number in PDB)		E39 V325 Q326 F327 R526 N542
Binding residue
(residue number reindexed from 1)		E25 V306 Q307 F308 R429 N445
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031491 nucleosome binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links

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