Structure of PDB 5wbk Chain A Binding Site BS01

Receptor Information
>5wbk Chain A (length=1053) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATSMAYLPQTIVLCELRHDASEASAPLGTSEIVLVPKWRLKERMKTGCVA
LVLCLNITVDPPDVCARIEAWIDPFSMAPPKALETIGKNLSTQYERWQPR
ARYKVQLDPTVDEVRKLCLTCRKYAKTERVLFHYNGHGVPKPTANGEIWV
FNKSYTQYIPLPISELDSWLKTPSIYVFDCSAARMILNAFAELHDWGSSG
SSGSSRDCILLAACDVHETLPQSVEFPADVFTSCLTTPIKMALKWFCRRS
LLKEIIDESLIDRIPGRQNDRKTLLGELNWIFTAVTDTIAWNVLPHELFQ
RLFRQDLLVASLFRNFLLAERIMRSANCNPISHPMLPPTHQHHMWDAWDM
AAEICLSQLPQLVLDPSTEFQPSPFFTEQLTAFEVWLDHGSEHKKPPEQL
PIVLQVLLSQCHRFRALVLLGRFLDMGSWAVDLALSVGIFPYVLKLLQTT
TNELRQILVFIWTKILALDKSCQIDLVKDGGHTYFIRFLDSSGAFPEQRA
MAAFVLAVIVDGHRRGQEACLEANLIGVCLGHLEEPLFLQWLCLCLGKLW
EDFMEAQIMGREANAFEKLAPLLSEPQPEVRAAAVFALGTLLDEFDDDEK
IRAEDAIIKSLLDVVSDGSPLVRAEVAVALARFAFGHKQHLKLAAASYWA
VYSQCVRAMFALAKDPSPRIASLGRRVLSIIGIEERSLLPLSTIYGWSCG
HFSKPLSQEIAAKREEKEKFALEHIAKCQHSSISKLNNNPIANWDTRFET
GTKTALLHPFSPIVVAADENERIRVWNYEEATLLNGFDNHDFPDKGISKL
CLINELDDSLLLVASCDGSVRIWKNYATKGKQKLVTGFSSIQLNAVVDWQ
QQSGYLYASGETSTVTLWDLEKEQLVRSVPSESECGVTALSASQVHGGQL
AAGFADGSLRLYDVRSPEPLVCATRPHQKVERVVGLSFQPGLDPAKVVSA
SQAGDIQFLDLRTTRDTYLTIDAHRGSLTALAVHRHAPIIASGSAKQLIK
VFSLQGEQLGIIRYYPSFMAQKIGSVSCLTFHPYQVLLAAGAADSFVSIY
THD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wbk Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Resolution3.11 Å
Binding residue
(original residue number in PDB)		R103 R336 T348 D352 R369 L372 L469 Q470 L473 R478 Y507
Binding residue
(residue number reindexed from 1)		R43 R271 T283 D287 R304 L307 L404 Q405 L408 R413 Y442
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019900 kinase binding
Biological Process
GO:0009793 embryo development ending in seed dormancy
GO:0010492 maintenance of shoot apical meristem identity
GO:0010507 negative regulation of autophagy
GO:0031929 TOR signaling
Cellular Component
GO:0005737 cytoplasm
GO:0031931 TORC1 complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wbk, PDBe:5wbk, PDBj:5wbk
PDBsum5wbk
PubMed29236692
UniProtQ93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1 (Gene Name=RAPTOR1)

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