Structure of PDB 5vaq Chain A Binding Site BS01

Receptor Information
>5vaq Chain A (length=861) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSGDGRAIWSLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI
HTHLKGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAK
GLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFND
YATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVG
HNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQ
QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFF
AFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWF
TDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQD
AYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQ
FPCDFSWGVTESVLKPECTDFVNIKKQLEMLARMKVTHYRFALDWASVLP
TGQLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA
DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDT
YGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHW
RAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTE
AERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSS
PTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLG
KYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFY
NKVISSRGFPF
Ligand information
>5vaq Chain C (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PDVGSSDPLSMVGGSQGRSPSYES
Receptor-Ligand Complex Structure
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PDB5vaq Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Resolution2.606 Å
Binding residue
(original residue number in PDB)		F379 K380 V392 W419 F420 D422 Y434 M435 S532 Y643 P644 H646 N692 E693 R696 L697 H743 F826 R829 R845 Q848 F849 L850 I853 F931 F942
Binding residue
(residue number reindexed from 1)		F309 K310 V322 W349 F350 D352 Y364 M365 S462 Y535 P536 H538 N584 E585 R588 L589 H635 F718 R721 R737 Q740 F741 L742 I745 F823 F834
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vaq, PDBe:5vaq, PDBj:5vaq
PDBsum5vaq
PubMed29342135
UniProtQ86Z14|KLOTB_HUMAN Beta-klotho (Gene Name=KLB)

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