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BioLiP

Structure of PDB 5o45 Chain A Binding Site BS01

Receptor Information
>5o45 Chain A (length=129) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQ
FVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMI
SYGGADYKRITVKVNAPYAAALEHHHHHH
Ligand information
>5o45 Chain B (length=14) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FFKGDVFYGWYLCG
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5o45 Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Resolution0.99 Å
Binding residue
(original residue number in PDB)		Y56 E58 E60 D61 N63 Q66 V68 M115 I116 S117 D122 Y123
Binding residue
(residue number reindexed from 1)		Y40 E42 E44 D45 N47 Q50 V52 M99 I100 S101 D106 Y107
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5o45, PDBe:5o45, PDBj:5o45
PDBsum5o45
PubMed28881104
UniProtQ9NZQ7|PD1L1_HUMAN Programmed cell death 1 ligand 1 (Gene Name=CD274)

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