Structure of PDB 5ncl Chain A Binding Site BS01

Receptor Information

>5ncl Chain A (length=418) Species: 4932 (Saccharomyces cerevisiae)

MYFERRPDLLTKGTQDKAAAVKLKIENFYQSSVKYAIERNERRVELETEL
TSHNWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGE
VRLVQKKDTGKIYAMKTLLKSEMYKKSDSPWVVSLYYSFQDAQYLYLIME
FLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPDN
ILIDIRGHIKLSDFGLSTGFHKTHDSNYYSISLTMSNRQQIQTWRKSRRL
MAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETP
QETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEI
KSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENVPDSPAMLP
FIGYTYSRFDYLTRKNAL

Ligand information

>5ncl Chain D (length=5) Species: 4932 (Saccharomyces cerevisiae)

DFKFP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ncl Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface.
• Resolution: 3.15 Å
• Binding residue (original residue number in PDB): D450 R453 F454 G674 P686
• Binding residue (residue number reindexed from 1): D170 R173 F174 G358 P370

Enzymatic activity

• Catalytic site (original residue number in PDB): A475 K477 N480 D493 S563 T574
• Catalytic site (residue number reindexed from 1): A195 K197 N200 D213 S247 T258
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5ncl, PDBe:5ncl, PDBj:5ncl
• PDBsum: 5ncl
• PubMed: 32250593
• UniProt: P53894|CBK1_YEAST Serine/threonine-protein kinase CBK1 (Gene Name=CBK1)