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BioLiP

Structure of PDB 5ht2 Chain A Binding Site BS01

Receptor Information
>5ht2 Chain A (length=255) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVI
PPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKM
MRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDS
TTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNN
LRIPAAYKHRFDRIFFRAEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCT
LNVVL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ht2 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Resolution1.43 Å
Binding residue
(original residue number in PDB)		H236 S239 T240 D272 N274 R276 W307 I317 Y321 F325 H359
Binding residue
(residue number reindexed from 1)		H122 S125 T126 D158 N160 R162 W193 I203 Y207 F211 H244
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

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Molecular Function
External links
PDB RCSB:5ht2, PDBe:5ht2, PDBj:5ht2
PDBsum5ht2
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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