Structure of PDB 5eod Chain A Binding Site BS01

Receptor Information
>5eod Chain A (length=586) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSED
PTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLD
MKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKH
TQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVM
APDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRI
KKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQK
LCTNAVRCQFFTYTPAQNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLR
LCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIG
NQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQY
KMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYD
KIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYKGDSGGPLSCKHN
EVWHLVGITSWGEGCERPGVYTNVVEYVDWILEKTQ
Ligand information
Receptor-Ligand Complex Structure
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PDB5eod A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K103 N106 S109 A134 H143 L148 L163
Binding residue
(residue number reindexed from 1)		K102 N105 S108 A133 H142 L147 L162
Enzymatic activity
Catalytic site (original residue number in PDB) H413 D462 K554 G555 D556 S557 G558
Catalytic site (residue number reindexed from 1) H409 D458 K538 G539 D540 S541 G542
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008236 serine-type peptidase activity
GO:0070009 serine-type aminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0030193 regulation of blood coagulation
GO:0031639 plasminogen activation
GO:0051919 positive regulation of fibrinolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5eod, PDBe:5eod, PDBj:5eod
PDBsum5eod
PubMed27006387
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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