Structure of PDB 5c65 Chain A Binding Site BS01

Receptor Information
>5c65 Chain A (length=457) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFIQKTLTDKGNAPP
SEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTG
GCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAF
GTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPF
CPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQ
VTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAPIYAT
IGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDM
SFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTS
NFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDIT
RAFEGQA
Ligand information
Ligand ID37X
InChIInChI=1S/C27H52O12/c1-3-5-7-9-11-27(12-10-8-6-4-2,15-36-25-23(34)21(32)19(30)17(13-28)38-25)16-37-26-24(35)22(33)20(31)18(14-29)39-26/h17-26,28-35H,3-16H2,1-2H3/t17-,18-,19-,20-,21+,22+,23-,24-,25-,26-/m0/s1
InChIKeyTYXCLOLHZMMLEK-RNDJEAJNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.9.2CCCCCCC(CCCCCC)(COC1C(C(C(C(O1)CO)O)O)O)COC2C(C(C(C(O2)CO)O)O)O
ACDLabs 12.01O(CC(CCCCCC)(CCCCCC)COC1OC(CO)C(O)C(O)C1O)C2OC(C(O)C(O)C2O)CO
OpenEye OEToolkits 1.9.2CCCCCCC(CCCCCC)(CO[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)CO)O)O)O)CO[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)CO)O)O)O
CACTVS 3.385CCCCCCC(CCCCCC)(CO[CH]1O[CH](CO)[CH](O)[CH](O)[CH]1O)CO[CH]2O[CH](CO)[CH](O)[CH](O)[CH]2O
CACTVS 3.385CCCCCCC(CCCCCC)(CO[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O)CO[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O
FormulaC27 H52 O12
NameOctyl Glucose Neopentyl Glycol
ChEMBL
DrugBank
ZINCZINC000098208404
PDB chain5c65 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5c65 Structure of the human glucose transporter GLUT3 / SLC2A3
Resolution2.65 Å
Binding residue
(original residue number in PDB)		R91 P203
Binding residue
(residue number reindexed from 1)		R87 P199
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005353 fructose transmembrane transporter activity
GO:0005354 galactose transmembrane transporter activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0015755 fructose transmembrane transport
GO:0015757 galactose transmembrane transport
GO:0019852 L-ascorbic acid metabolic process
GO:0046323 D-glucose import
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
GO:0098708 D-glucose import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1904659 D-glucose transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0030667 secretory granule membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5c65, PDBe:5c65, PDBj:5c65
PDBsum5c65
PubMed
UniProtP11169|GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (Gene Name=SLC2A3)

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