Structure of PDB 4z2d Chain A Binding Site BS01

Receptor Information

>4z2d Chain A (length=485) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMN
ELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLV
DGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANE
REPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEV
TTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKT
GRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFV
IEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAY
IEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDA
EAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADL
ADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV

Ligand information

>4z2d Chain E (length=7) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gttgtat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4z2d Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution	3.38 Å
Binding residue (original residue number in PDB)	R30 H43 H76 H78 I172
Binding residue (residue number reindexed from 1)	R29 H42 H75 H77 I171

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:4z2d, PDBe:4z2d, PDBj:4z2d
PDBsum	4z2d
PubMed
UniProt	Q8DPM2\|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

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