Structure of PDB 4wz9 Chain A Binding Site BS01

Receptor Information
>4wz9 Chain A (length=882) Species: 7165 (Anopheles gambiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QAVDERYRLPTTSIPIHYDLHLRTEIHRNERTFTGTVGIQLQVVQATDKL
VMHNRGLVMSSAKVSSLPNGVTGAPTLIGDVQYSTDTTFEHITFTSPTIL
QPGTYLLEVAFQGRLATNDDGFYVSSYVADNGERRYLATTQFESTSARMA
FPCYDEPGLKATFTVSITHSLSYKAISNMPQKTTTDIETDMRTTFFEKTP
AMSTYLLAFVVSDFQLRLSGAQRVYVRPNAFNEATFALEAGVKILKVLDD
HLGIPYDTYMPKLDQIAIPDFAAGAMENWGLVTYREQALLFNPAVSTYRG
KTNVATTIAHEYAHQWFGNLVSPEWWEYIWLNEGFATLYEFYALDMAYPG
QEYWELFNQQVIQYAMGQDGQASTRPMNWNAATPGEISALFDRVAYDKSG
SVLNMMRHVLGDDNWKAGLKAYLTDRALQGAVDEQLYAGLQSAIEGKGVL
PNGVTVAQIMRTWTNEAGYPVLNVRRSYDTGDVIISQERFYNDRKVPNTN
IWMIPYNYVHQAKADFNEFDDFQWLATKAARIETTVPANEWIVFNKQQVG
YYRVNYDEHNWELITNALHENWASIHRLNRAQLIDDAYWLARSGRLDLRV
ALRFMTYLRNEREYAPWTAANVALTYFNNRLRGTAEYHNFLIFVDALIED
IYSLLTIDAVSPDDTLLHKYLVQTISTWACSMGYTDCLMKTAALLKAEAS
GTGPAVHPDIASVTYCYGMRSALESEFQYLYRKMMNSKNLAERTMLIDSL
GCSNNKEFLKAFLTTALGSINYRADERRRVVQAIYSGGRTGVDALIEFLM
DPALVNEFVSTLSTSTLNSALSAIASRTNNVEEMNKLNALITALGSRVNS
QTAANLRTTAQANLDWVNGFEGLMLSNFLAEA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4wz9 The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		G330 A331 M332 E333 R341 H366 E367 E389 Y452
Binding residue
(residue number reindexed from 1)		G274 A275 M276 E277 R285 H310 E311 E333 Y396
Enzymatic activity
Catalytic site (original residue number in PDB) E333 H366 E367 H370 E389 S444 Y452
Catalytic site (residue number reindexed from 1) E277 H310 E311 H314 E333 S388 Y396
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0098552 side of membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4wz9, PDBe:4wz9, PDBj:4wz9
PDBsum4wz9
PubMed26075520
UniProtQ7Q2T8|AMPN_ANOGA Aminopeptidase N (Gene Name=APN1)

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