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BioLiP

Structure of PDB 4p6x Chain A Binding Site BS01

Receptor Information
>4p6x Chain A (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMALMAFALGWRSYRQSSANLLYFAP
DLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKVLLLLSTI
PKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSM
HEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFH
QK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4p6x Structures and mechanism for the design of highly potent glucocorticoids.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		V575 R585 L589 M593 L596 E755
Binding residue
(residue number reindexed from 1)		V50 R60 L64 M68 L71 E230
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:4p6x, PDBe:4p6x, PDBj:4p6x
PDBsum4p6x
PubMed24763108
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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