Structure of PDB 4kr3 Chain A Binding Site BS01

Receptor Information
>4kr3 Chain A (length=466) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDRAKMGDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQH
FIQEEQILEIDCTMLTPEPVLKTSGHVDKFSFNLMFKTFIGPGGNMPGYL
RPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREF
TMAEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAV
EQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENACDCWDAESKT
SYGWIEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVFQKTLY
VEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKC
SVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGV
AFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITW
ADVEARYPLFEGQETG
Ligand information
>4kr3 Chain C (length=70) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgccgcugguguagugguaucaugcaagauucccauucuugcgacccgg
guucgauucccgggcggcgc
<<<<<<<..<<<.........>>><<<<<<.......>>>>>>...<<<<
<.......>>>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB4kr3 Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation
Resolution3.235 Å
Binding residue
(original residue number in PDB)		D72 R76 Q82 G88 G89 V90 S91 S281 R283 Q547 R548 L567 S568 S599 G601 R602 Y604 A605 R606 E609 T617 D619 F620 T631 R633 M638 Q640 Q675
Binding residue
(residue number reindexed from 1)		D8 R12 Q18 G24 G25 V26 S27 S139 R141 Q335 R336 L355 S356 S387 G389 R390 Y392 A393 R394 E397 T405 D407 F408 T419 R421 M426 Q428 Q463
Enzymatic activity
Enzyme Commision number 2.7.7.-
6.1.1.14: glycine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004820 glycine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006426 glycyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kr3, PDBe:4kr3, PDBj:4kr3
PDBsum4kr3
PubMed24898252
UniProtP41250|GARS_HUMAN Glycine--tRNA ligase (Gene Name=GARS1)

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