Structure of PDB 4kr2 Chain A Binding Site BS01

Receptor Information
>4kr2 Chain A (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVDRAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQ
HFIQEEQILEIDCTMLTPEPVLKTSGHVDFNLMFKTFIGPGGNMPGYLRP
ETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTM
AEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQ
GVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMECDCWDAESKTSYGW
IEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVRFQKTLYVEEVVP
NVIEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLS
QNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGVAFGVTI
DFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVEAR
YPLFEGQE
Ligand information
>4kr2 Chain C (length=69) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgccgcugguguagugguaucaugcaagauucccauucuugcgacccgg
guucgauucccgggcggcg
.<<<<<<..<<<.........>>><<<<<<.......>>>>>>...<<<<
<.......>>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB4kr2 Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation
Resolution3.292 Å
Binding residue
(original residue number in PDB)		D72 Q82 G88 G89 S91 R283 Q547 R548 L567 S568 S596 S597 S599 G601 R602 Y604 A605 R606 E609 T617 R633 M638 Q640 F672 Q675
Binding residue
(residue number reindexed from 1)		D9 Q19 G25 G26 S28 R139 Q329 R330 L349 S350 S378 S379 S381 G383 R384 Y386 A387 R388 E391 T399 R415 M420 Q422 F454 Q457
Enzymatic activity
Enzyme Commision number 2.7.7.-
6.1.1.14: glycine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004820 glycine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006426 glycyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kr2, PDBe:4kr2, PDBj:4kr2
PDBsum4kr2
PubMed24898252
UniProtP41250|GARS_HUMAN Glycine--tRNA ligase (Gene Name=GARS1)

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