BioLiP

Structure of PDB 4imq Chain A Binding Site BS01

Receptor Information

>4imq Chain A (length=173) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GSAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIA
IHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLA
VRMGAIASMRIQGRLVHGQSGMLLGTIPGDCGAPYVHKRGNDWVVCGVHA
AATKSGNTVVCAVQAGEGETALE

Ligand information

>4imq Chain B (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tLFE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4imq Structural basis of substrate specificity and protease inhibition in norwalk virus.
Resolution	1.5 Å
Binding residue (original residue number in PDB)	H30 E54 I109 Q110 V114 T134 I135 P136 C139 A158 A159 A160 T161 K162
Binding residue (residue number reindexed from 1)	H32 E56 I111 Q112 V116 T126 I127 P128 C131 A150 A151 A152 T153 K154

Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

	Molecular Function
GO:0004197	cysteine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

PDB	RCSB:4imq, PDBe:4imq, PDBj:4imq
PDBsum	4imq
PubMed	23365454
UniProt	Q83883\|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)