Structure of PDB 4a4b Chain A Binding Site BS01

Receptor Information
>4a4b Chain A (length=388) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRT
ILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQP
RRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEK
TIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRL
FQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSC
TRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNP
DLTGLCEPTPQDHIKVTQEQFELYCEMGSTFQLCKICAENDKDVKIEPCG
HLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4a4b Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Resolution2.789 Å
Binding residue
(original residue number in PDB)		Y274 R294 S296 C297 T298 Y307 Q316 T317 P319 F336 Y337
Binding residue
(residue number reindexed from 1)		Y227 R247 S249 C250 T251 Y260 Q269 T270 P272 F289 Y290
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:4a4b, PDBe:4a4b, PDBj:4a4b
PDBsum4a4b
PubMed22266821
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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