Structure of PDB 3rse Chain A Binding Site BS01

Receptor Information

>3rse Chain A (length=396) Species: 9913 (Bos taurus)

AGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKKGVDDLDFFIGDE
AIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEP
PLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
TVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGI
PPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKK
EFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPL
YKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSKPKPIDVQVIT
HHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFG

Ligand information

>3rse Chain Z (length=3) Species: 9913 (Bos taurus)

EWE

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3rse Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex.
• Resolution: 2.65 Å
• Binding residue (original residue number in PDB): P236 D330 R333 R334 R341
• Binding residue (residue number reindexed from 1): P221 D315 R318 R319 R326

Gene Ontology

Molecular Function

• GO:0003779 actin binding
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0051015 actin filament binding

Biological Process

• GO:0010592 positive regulation of lamellipodium assembly
• GO:0030030 cell projection organization
• GO:0034314 Arp2/3 complex-mediated actin nucleation
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0060271 cilium assembly

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0005885 Arp2/3 protein complex
• GO:0035861 site of double-strand break
• GO:0042995 cell projection

External links

• PDB: RCSB:3rse, PDBe:3rse, PDBj:3rse
• PDBsum: 3rse
• PubMed: 21676862
• UniProt: P61157|ARP3_BOVIN Actin-related protein 3 (Gene Name=ACTR3)