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BioLiP

Structure of PDB 3p4u Chain A Binding Site BS01

Receptor Information
>3p4u Chain A (length=145) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSD
LGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAY
DAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3p4u Crystal structures of active and inhibitor-bound human Casp6
Resolution1.9 Å
Binding residue
(original residue number in PDB)		R64 R65 H121 Q161 C163
Binding residue
(residue number reindexed from 1)		R34 R35 H91 Q131 C133
Enzymatic activity
Catalytic site (original residue number in PDB) P62 E63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1) P32 E33 H91 G92 C133 R134
Enzyme Commision number 3.4.22.59: caspase-6.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3p4u, PDBe:3p4u, PDBj:3p4u
PDBsum3p4u
PubMed
UniProtP55212|CASP6_HUMAN Caspase-6 (Gene Name=CASP6)

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