Structure of PDB 3jzr Chain A Binding Site BS01

Receptor Information
>3jzr Chain A (length=97) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKR
LYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQ
Ligand information
Receptor-Ligand Complex Structure
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PDB3jzr Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		S17 Q24 L54 L57 G58 I61 M62 Y67 Q72 H73 V93 K94 H96
Binding residue
(residue number reindexed from 1)		S2 Q9 L39 L42 G43 I46 M47 Y52 Q57 H58 V78 K79 H81
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3jzr, PDBe:3jzr, PDBj:3jzr
PDBsum3jzr
PubMed19910468
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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