Structure of PDB 2lty Chain A Binding Site BS01
Receptor Information
>2lty Chain A (length=34) Species:
9606
(Homo sapiens) [
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PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIG
Ligand information
>2lty Chain B (length=15) Species:
9606
(Homo sapiens) [
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ELESPPPPYSRYPMD
Receptor-Ligand Complex Structure
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PDB
2lty
Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Resolution
N/A
Binding residue
(original residue number in PDB)
R374 K378 R380 Y382 V384 N385 H386 R389 T391 W393
Binding residue
(residue number reindexed from 1)
R10 K14 R16 Y18 V20 N21 H22 R25 T27 W29
Enzymatic activity
Enzyme Commision number
2.3.2.26
: HECT-type E3 ubiquitin transferase.
2.3.2.36
: RING-type E3 ubiquitin transferase (cysteine targeting).
External links
PDB
RCSB:2lty
,
PDBe:2lty
,
PDBj:2lty
PDBsum
2lty
PubMed
22921829
UniProt
Q96PU5
|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)
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