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Structure of PDB 2laj Chain A Binding Site BS01

Receptor Information

>2laj Chain A (length=40) Species: 9606 (Homo sapiens)

QSFLPPGWEMRIAPNGRPFFYDHNTKTTTWEDPRLKFPVH

Ligand information

>2laj Chain B (length=10) Species: 9606 (Homo sapiens)

AGSPNLSPNP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2laj A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
• Resolution: N/A
• Binding residue (original residue number in PDB): E484 R486 N490 R492 F494 Y496 T503 W505
• Binding residue (residue number reindexed from 1): E9 R11 N15 R17 F19 Y21 T28 W30

Enzymatic activity

• Enzyme Commision number: 2.3.2.26: HECT-type E3 ubiquitin transferase.
  2.3.2.36: RING-type E3 ubiquitin transferase (cysteine targeting).

External links

• PDB: RCSB:2laj, PDBe:2laj, PDBj:2laj
• PDBsum: 2laj
• PubMed: 21685363
• UniProt: Q96PU5|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)

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