Structure of PDB 2gvq Chain A Binding Site BS01

Receptor Information
>2gvq Chain A (length=340) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNINEILKKLINKSDLEINEAEELAKAIIRGEVPEILVSAILVALRMKGE
SKNEIVGFARAMRELAIKIDVPNAIDTAGTGLGTVNVSTASAILLSLVNP
VAKHGNRAVSGKSGSADVLEALGYNIIVPPERAKELVNKTNFVFLFAQYY
HPAMKNVANVRKTLGIRTIFNILGPLTNPANAKYQLMGVFSKDHLDLLSK
SAYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVTDFGI
SPIPIEKLIVNSAEDSAIKIVRAFLGKDEHVAEFIKINTAVALFALDRVG
DFREGYEYADHLIEKSLDKLNEIISMNGDVTKLKTIVVKS
Ligand information
Ligand IDBE2
InChIInChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)
InChIKeyRWZYAGGXGHYGMB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Nc1ccccc1C(O)=O
ACDLabs 10.04O=C(O)c1ccccc1N
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)O)N
FormulaC7 H7 N O2
Name2-AMINOBENZOIC ACID
ChEMBLCHEMBL14173
DrugBankDB04166
ZINCZINC000000047985
PDB chain2gvq Chain A Residue 346 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2gvq Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
Resolution2.43 Å
Binding residue
(original residue number in PDB)		N109 A150 Q151 H154 R164 G177
Binding residue
(residue number reindexed from 1)		N106 A147 Q148 H151 R161 G174
Annotation score5
Enzymatic activity
Enzyme Commision number 2.4.2.18: anthranilate phosphoribosyltransferase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004048 anthranilate phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000162 tryptophan biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2gvq, PDBe:2gvq, PDBj:2gvq
PDBsum2gvq
PubMed16714288
UniProtP50384|TRPD_SACS2 Anthranilate phosphoribosyltransferase (Gene Name=trpD)

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