BioLiP

Structure of PDB 1lvm Chain A Binding Site BS01

Receptor Information

>1lvm Chain A (length=229) Species: 12227 (Tobacco etch virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GHHHHHHHGESLFKGPRDYNPISSTICHLTNESDGHTTSLYGIGFGPFII
TNKHLFRRNNGTLLVQSLHGVFKVKNTTTLQQHLIDGRDMIIIRMPKDFP
PFPQKLKFREPQREERICLVTTNFQTKSMSSMVSDTSCTFPSSDGIFWKH
WIQTKDGQCGSPLVSTRDGFIVGIHSASNFTNTNNYFTSVPKNFMELLTN
QEAQQWVSGWRLNADSVLWGGHKVFMDKP

Ligand information

>1lvm Chain C (length=6) Species: 12227 (Tobacco etch virus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ENLYFQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1lvm Structural basis for the substrate specificity of tobacco etch virus protease.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	H46 D81 T146 C151 H167 S168 A169 S170 N171 F172 N174 N176 Y178 H214 K215 V216 F217 M218 K220
Binding residue (residue number reindexed from 1)	H54 D89 T154 C159 H175 S176 A177 S178 N179 F180 N182 N184 Y186 H222 K223 V224 F225 M226 K228

Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.
3.4.-.-
3.4.22.44: nuclear-inclusion-a endopeptidase.
3.4.22.45: helper-component proteinase.
3.6.4.-

Gene Ontology

	Molecular Function
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Biological Process

PDB	RCSB:1lvm, PDBe:1lvm, PDBj:1lvm
PDBsum	1lvm
PubMed	12377789
UniProt	P04517\|POLG_TEV Genome polyprotein