Structure of PDB 1iid Chain A Binding Site BS01

Receptor Information

>1iid Chain A (length=422) Species: 4932 (Saccharomyces cerevisiae)

AMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFEWCS
IDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDW
HIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLT
PVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYTHRPLNWKKLYEVD
FTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRF
ELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLP
FTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYD
ACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFLNFYLFNYRAKPIT
GGLNPDNSNDIKRRSNVGVVML

Ligand information

>1iid Chain O (length=8)

GLYASKLA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1iid Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): Y103 F113 Y219 H221 F334 Y349 G416 D417 G418 M454 L455
• Binding residue (residue number reindexed from 1): Y70 F80 Y186 H188 F301 Y316 G383 D384 G385 M421 L422

Enzymatic activity

• Catalytic site (original residue number in PDB): N169 F170 L171 T205 L455
• Catalytic site (residue number reindexed from 1): N136 F137 L138 T172 L422
• Enzyme Commision number: 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
• GO:0016746 acyltransferase activity

Biological Process

• GO:0006499 N-terminal protein myristoylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1iid, PDBe:1iid, PDBj:1iid
• PDBsum: 1iid
• PubMed: 11371195
• UniProt: P14743|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)