Structure of PDB 1emj Chain A Binding Site BS01

Receptor Information
>1emj Chain A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEFFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQM
CDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDI
EDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGC
RHFSKTNELLQKSGKKPIDWKEL
Ligand information
Receptor-Ligand Complex Structure
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PDB1emj Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D145 Y147 H148 P168 S169 G246 S247 H268 S270 P271 L272 S273 R276
Binding residue
(residue number reindexed from 1)		D64 Y66 H67 P87 S88 G165 S166 H187 S189 P190 L191 S192 R195
Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1emj, PDBe:1emj, PDBj:1emj
PDBsum1emj
PubMed10805771
UniProtP13051|UNG_HUMAN Uracil-DNA glycosylase (Gene Name=UNG)

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