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BioLiP

Structure of PDB 1e27 Chain A Binding Site BS01

Receptor Information
>1e27 Chain A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRAP
WIEQEGPEYWDRNTQIFKTNTQTYRENLRIALRYYNQSEAGSHTWQTMYG
CDVGPDGRLLRGHNQYAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAA
REAEQLRAYLEGLCVEWLRRHLENGKETLQRADPPKTHVTHHPVSDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRWEP
Ligand information
>1e27 Chain C (length=9) Species: 11676 (Human immunodeficiency virus 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LPPVVAKEI
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1e27 Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y7 Y9 N63 I66 F67 N70 T73 E76 N77 I80 Y84 Y99 T143 K146 W147 E152 Y159 W167
Binding residue
(residue number reindexed from 1)		Y7 Y9 N63 I66 F67 N70 T73 E76 N77 I80 Y84 Y99 T143 K146 W147 E152 Y159 W167
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:1e27, PDBe:1e27, PDBj:1e27
PDBsum1e27
PubMed10975842
UniProtP01889|HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain (Gene Name=HLA-B)

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