BioLiP

Structure of PDB 1cws Chain A Binding Site BS01

Receptor Information

>1cws Chain A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFV
IVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFH
CEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNF
CEPQDYRPMNHEAFKDELKTFRLKTRSW

Ligand information

Ligand ID

WO4

InChI

InChI=1S/4O.W/q;;2*-1;

InChIKey

PBYZMCDFOULPGH-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	[O-][W](=O)(=O)[O-]
ACDLabs 10.04 CACTVS 3.341	[O-][W]([O-])(=O)=O

Formula

O4 W

Name

TUNGSTATE(VI)ION

ChEMBL

DrugBank

ZINC

PDB chain

1cws Chain A Residue 567 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1cws Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	C473 E474 F475 S476 S477 E478 R479 W550
Binding residue (residue number reindexed from 1)	C101 E102 F103 S104 S105 E106 R107 W178
Annotation score	1
Binding affinity	BindingDB: IC50=30000nM

Enzymatic activity

Enzyme Commision number

3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

	Molecular Function
GO:0004725	protein tyrosine phosphatase activity

	Biological Process
GO:0006470	protein dephosphorylation
GO:1902751	positive regulation of cell cycle G2/M phase transition

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Molecular Function

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Biological Process

PDB	RCSB:1cws, PDBe:1cws, PDBj:1cws
PDBsum	1cws
PubMed	10543950
UniProt	P30305\|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)