Structure of PDB 1a31 Chain A Binding Site BS01

Receptor Information
>1a31 Chain A (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML
DHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTE
ARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGR
GNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV
SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYRED
WKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL
HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL
FDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA
KILSYNRANRAVKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAID
MADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1a31 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		R364 V410 T411 W412 I424 Y426 M428 K436 K439 K443 K587 N722 Y723
Binding residue
(residue number reindexed from 1)		R150 V196 T197 W198 I210 Y212 M214 K222 K225 K229 K373 N415 Y416
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a31, PDBe:1a31, PDBj:1a31
PDBsum1a31
PubMed9488644
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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