Structure of PDB 10mh Chain A Binding Site BS01
Receptor Information
>10mh Chain A (length=327) Species:
726
(Haemophilus haemolyticus) [
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MIEIKDKQLTGLRFIDLFAGLGGFRLALESCGAECVYSNEWDKYAQEVYE
MNFGEKPEGDITQVNEKTIPDHDILCAGFPCQAFSISGKQKGFEDSRGTL
FFDIARIVREKKPKVVFMENVKNFASHDNGNTLEVVKNTMNELDYSFHAK
VLNALDYGIPQKRERIYMICFRNDLNIQNFQFPKPFELNTFVKDLLLPDS
EVEHLVIDRKDLVMTNQEIEQTTPKTVRLGIVGKGGQGERIYSTRGIAIT
LSAYGGGIFAKTGGYLVNGKTRKLHPRECARVMGYPDSYKVHPSTSQAYK
QFGNSVVINVLQYIAYNIGSSLNFKPY
Ligand information
>10mh Chain B (length=12) [
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ccatgcgctgac
Receptor-Ligand Complex Structure
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PDB
10mh
Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
Resolution
2.55 Å
Binding residue
(original residue number in PDB)
I86 Q90 R209 G236 Q237 G256 G257
Binding residue
(residue number reindexed from 1)
I86 Q90 R209 G236 Q237 G256 G257
Enzymatic activity
Catalytic site (original residue number in PDB)
C81 E119 R163 R165
Catalytic site (residue number reindexed from 1)
C81 E119 R163 R165
Enzyme Commision number
2.1.1.37
: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003886
DNA (cytosine-5-)-methyltransferase activity
GO:0008168
methyltransferase activity
Biological Process
GO:0009307
DNA restriction-modification system
GO:0032259
methylation
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Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:10mh
,
PDBe:10mh
,
PDBj:10mh
PDBsum
10mh
PubMed
9925782
UniProt
P05102
|MTH1_HAEPH Type II methyltransferase M.HhaI (Gene Name=hhaIM)
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