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Structure of PDB 7o4k Chain 7 Binding Site BS01

Receptor Information
>7o4k Chain 7 (length=608) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPL
AEQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDR
LSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDS
VIGVHSFEIANESVEVVKKRCQEIDYPVLEEYDFRNDHRNPDLDIDLKPS
TQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIV
LCTSSVSVMQWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSM
VANTRNRSHDSQKVMDFLTGREWGFIILDEVHVVPAAMFRRVVSTIAAHA
KLGLTATLVREDDKIGDLNFLIGPKLYEANWMELSQKGHIANVQCAEVWC
PMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHERRGDKIIVFS
DNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGD
TSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLV
SKDTQEMYYSTKRQAFLVDQGYAFKVITHLHGMENIPNLAYASPRERREL
LQEVLLKN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7o4k Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		A495 M497 F498 E520 H676 Y677 G678 S679
Binding residue
(residue number reindexed from 1)		A336 M338 F339 E361 H517 Y518 G519 S520
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000019 regulation of mitotic recombination
GO:0001111 RNA polymerase II promoter clearance
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0005829 cytosol
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o4k, PDBe:7o4k, PDBj:7o4k
PDBsum7o4k
PubMed34133942
UniProtQ00578|RAD25_YEAST General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (Gene Name=SSL2)

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