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Structure of PDB 1y79 Chain 1 Binding Site BS01

Receptor Information
>1y79 Chain 1 (length=680) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTMNPFLVQSTLPYLAPHFDQIANHHYRPAFDEGMQQKRAEIAAIALNPQ
MPDFNNTILALEQSGELLTRVTSVFFAMTAAHTNDELQRLDEQFSAELAE
LANDIYLNGELFARVDAVWQRRESLGLDSESIRLVEVIHQRFVLAGAKLA
QADKAKLKVLNTEAATLTSQFNQRLLAANKSGGLVVNDIAQLAGMSEQEI
ALAAEAAREKGLDNKWLIPLLNTTQQPALAEMRDRATREKLFIAGWTRAE
KNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQMAKTPEAALNFM
REIVPAARQRASDELASIQAVIDKQQGGFSAQPWDWAFYAEQVRREKFDL
DEAQLKPYFELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIF
DHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPVIYNVCNYQK
PAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFP
SQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNASLFNKGYEMSEL
LSAALLDMRWHCLEENEAMQDVDDFELRALVAENMDLPAIPPRYRSSYFA
HIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGLRFREAILSRG
NSEDLERLYRQWRGKAPKIMPMLQHRGLNI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1y79 Chain 1 Residue 700 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1y79 Crystal Structure of the E.coli Dipeptidyl Carboxypeptidase Dcp: Further Indication of a Ligand-dependant Hinge Movement Mechanism
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H469 H473 E498
Binding residue
(residue number reindexed from 1)		H469 H473 E498
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H469 E470 H473
Catalytic site (residue number reindexed from 1) H469 E470 H473
Enzyme Commision number 3.4.15.5: peptidyl-dipeptidase Dcp.
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1y79, PDBe:1y79, PDBj:1y79
PDBsum1y79
PubMed15876371
UniProtP24171|DCP_ECOLI Dipeptidyl carboxypeptidase (Gene Name=dcp)

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