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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Sphingosine 1-phosphate
Molecular formula	C18H38NO5P
IUPAC name	[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
Molecular weight	379.478
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	1.9
Synonyms	Sphingosine-1-Phosphate (d18:1) (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate) 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)- B6707 Epitope ID:161059 NCGC00161364-02 sphingosin-1-phosphat YP-005 (2S,3R,E)-2-Amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate),(R-(R,S-(E)))- C06124 D-erythro-Sphingosine 1-phosphate, 96% I14-91220 S1P. Sphingosine 1-phosphate, >=95%, powder Sphingosine, D-erythro-1-phosphate [(2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate (2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol 1712AH AC1NR2K4 C1P(d18:1) DTXSID4037166 MolPort-003-850-277 Sphing-4-enine 1-phosphate SPN-1-P (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate) 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (R-(R,S-(E)))- BDBM50158348 CHEMBL225155 GTPL911 Phosphoric acid (2S,3R)-2-amino-3-hydroxy-4-octadecenyl ester Sphingosine 1 Phosphate YVE187NJ1U (2S,3R,E)-2-Amino-3-hydroxyoctadec-4-enyl dihydrogen phosphate C18-Sphingosine 1-phosphate D-erythro-Sphingosine-1-phosphate LMSP01050001 SCHEMBL2559423 Sphingosine 1-phosphate, >=98.0% (TLC) sphingosine-1-phosphate [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate 26993-30-6 AKOS024456554 CHEBI:37550 DUYSYHSSBDVJSM-KRWOKUGFSA-N NCGC00161364-01 Sphing-4-enine-1-phosphate UNII-YVE187NJ1U (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), [R-[R,S-(E)]]- BML3-D06 D-erythro-sphingosine 1-phosphate HSCI1_000397 S1P Sphingosine 1-phosphic acid ZINC8860500 (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol C18H38NO5P D07UGA LS-185514 SCHEMBL3886 [ Show all ]
Inchi Key	DUYSYHSSBDVJSM-KRWOKUGFSA-N
Inchi ID	InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
PubChem CID	5283560
ChEMBL	CHEMBL225155
IUPHAR	911
BindingDB	50158348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
553612	G-protein coupled receptor 12	P47775	GPR12	Homo sapiens (Human)	334
553615	G-protein coupled receptor 3	P46089	GPR3	Homo sapiens (Human)	330
553613	G-protein coupled receptor 6	Q6YNI2	Gpr6	Mus musculus (Mouse)	363
553607	Probable G-protein coupled receptor 63	Q9BZJ6	GPR63	Homo sapiens (Human)	419
553610	Putative P2Y purinoceptor 10	O00398	P2RY10	Homo sapiens (Human)	339
69599	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Homo sapiens (Human)	382
553611	Sphingosine 1-phosphate receptor 1	O08530	S1pr1	Mus musculus (Mouse)	382
69594	Sphingosine 1-phosphate receptor 2	O95136	S1PR2	Homo sapiens (Human)	353
553608	Sphingosine 1-phosphate receptor 2	P52592	S1pr2	Mus musculus (Mouse)	352
69597	Sphingosine 1-phosphate receptor 3	Q99500	S1PR3	Homo sapiens (Human)	378
553609	Sphingosine 1-phosphate receptor 3	Q9Z0U9	S1pr3	Mus musculus (Mouse)	378
69598	Sphingosine 1-phosphate receptor 4	O95977	S1PR4	Homo sapiens (Human)	384
553617	Sphingosine 1-phosphate receptor 4	Q9Z0L1	S1pr4	Mus musculus (Mouse)	386
69596	Sphingosine 1-phosphate receptor 5	Q9H228	S1PR5	Homo sapiens (Human)	398
553614	Sphingosine 1-phosphate receptor 5	Q91X56	S1pr5	Mus musculus (Mouse)	400
553616	Sphingosine 1-phosphate receptor 5	Q9JKM5	S1pr5	Rattus norvegicus (Rat)	400

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