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GLASS

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GPCR

Name	Sphingosine 1-phosphate receptor 4
Species	Homo sapiens (Human)
Gene	S1PR4
Synonym	S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 Endothelial differentiation G-protein coupled receptor 6 edg6 Sphingosine 1-phosphate receptor Edg-6 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProt	O95977
Protein Data Bank	N/A
GPCR-HGmod model	O95977
3D structure model	This predicted structure model is from GPCR-EXP O95977.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3230
IUPHAR	278
DrugBank	N/A

Ligand

Name	Sphingosine 1-phosphate
Molecular formula	C18H38NO5P
IUPAC name	[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
Molecular weight	379.478
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	1.9
Synonyms	4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), [R-[R,S-(E)]]- BML3-D06 D-erythro-sphingosine 1-phosphate HSCI1_000397 S1P UNII-YVE187NJ1U (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate C18H38NO5P D07UGA LS-185514 SCHEMBL3886 Sphingosine 1-phosphic acid ZINC8860500 (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)- B6707 Epitope ID:161059 NCGC00161364-02 sphingosin-1-phosphat Sphingosine-1-Phosphate (d18:1) (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate) 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate),(R-(R,S-(E)))- C06124 D-erythro-Sphingosine 1-phosphate, 96% I14-91220 S1P. Sphingosine 1-phosphate, >=95%, powder YP-005 (2S,3R,E)-2-Amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate AC1NR2K4 C1P(d18:1) DTXSID4037166 MolPort-003-850-277 Sphing-4-enine 1-phosphate Sphingosine, D-erythro-1-phosphate [(2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate (2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol 1712AH 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (R-(R,S-(E)))- BDBM50158348 CHEMBL225155 GTPL911 Phosphoric acid (2S,3R)-2-amino-3-hydroxy-4-octadecenyl ester Sphingosine 1 Phosphate SPN-1-P (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate) C18-Sphingosine 1-phosphate D-erythro-Sphingosine-1-phosphate LMSP01050001 SCHEMBL2559423 Sphingosine 1-phosphate, >=98.0% (TLC) YVE187NJ1U (2S,3R,E)-2-Amino-3-hydroxyoctadec-4-enyl dihydrogen phosphate 26993-30-6 AKOS024456554 CHEBI:37550 DUYSYHSSBDVJSM-KRWOKUGFSA-N NCGC00161364-01 Sphing-4-enine-1-phosphate sphingosine-1-phosphate [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate [ Show all ]
Inchi Key	DUYSYHSSBDVJSM-KRWOKUGFSA-N
Inchi ID	InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
PubChem CID	5283560
ChEMBL	CHEMBL225155
IUPHAR	911
BindingDB	50158348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7.9 nM	PMID17070046	BindingDB,ChEMBL
EC50	13.0 nM	PMID24900589	ChEMBL
EC50	37.0 nM	PMID15341948	BindingDB,ChEMBL
EC50	67.0 nM	PMID12270137, PMID17114004, PMID14732717	IUPHAR
EC50	164.0 nM	PMID20446681	BindingDB,ChEMBL
EC50	270.0 nM	PMID15982878, PMID14505636	BindingDB,ChEMBL
Emax	1.0 -	PMID15982878	ChEMBL
IC50	1.04 nM	PMID20304639	ChEMBL
IC50	2.4 nM	PMID19081720	BindingDB,ChEMBL
IC50	2.9 nM	PMID20446681	BindingDB,ChEMBL
IC50	23.0 nM	PMID15149705	BindingDB,ChEMBL
IC50	34.0 nM	PMID15615513	BindingDB,ChEMBL
IC50	100.0 - 794.328 nM	PMID12270137, PMID11967257	IUPHAR

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