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Full-chain sequence requirement: Please provide the full-chain sequecne if your domain structures contain the following conditions.

Some linkers between domains are overlapped.

Gaps or missed residues in the linker or core region.

Discontinuous domain with the sequence disconnect in the full sequence.

You do not know how the domain structures connect, e.g. domain A + domain B or domain B + domain A.

When you are not sure if your domain structures contain the abvove conditions.

DEMO can deal with these conditions according to the full-chain sequence automatically. For example, search for the optimal docking regions when there are overlap between domains or generate the structure of the missed residues.

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