GPCR Sequence:

>sp|Q8NH54|O56A3_HUMAN Olfactory receptor 56A3 OS=Homo sapiens GN=OR56A3 PE=1 SV=2
MTTHRNDTLSTEASDFLLNCFVRSPSWQHWLSLPLSLLFLLAVGANTTLLMTIWLEASLH
QPLYYLLSLLSLLDIVLCLTVIPKVLTIFWFDLRPISFPACFLQMYIMNCFLAMESCTFM
VMAYDRYVAICHPLRYPSIITDHFVVKAAMFILTRNVLMTLPIPILSAQLRYCGRNVIEN
CICANMSVSRLSCDDVTINHLYQFAGGWTLLGSDLILIFLSYTFILRAVLRLKAEGAVAK
ALSTCGSHFMLILFFSTILLVFVLTHVAKKKVSPDVPVLLNVLHHVIPAALNPIIYGVRT
QEIKQGMQRLLKKGC

Estimation of the GPCR-I-TASSER model for Q8NH54

C-score = 0.260
TM-score = 0.750 (estimated)
RMSD = 5.7 A (estimated)

Here, C-score is a confidence score of the GPCR-I-TASSER predictions which is typically in [-5,2]. TM-score and RMSD measure how close the model is to the native structure and both are estimated based on the C-score. TM-score is in [0,1] with a value >0.5 implying the model of correct topology. The TM-score and RMSD estimations are made only for the first model because absolute values of TM-score and RMSD for the lower-rank models do not strongly correlate with the C-score. The models are ranked based on the structure density of GPCR-I-TASSER simulations.

The top ten threading templates used by GPCR-I-TASSER

Rank	PDB ID	Z-score	Download Templates
1	3emlA1	2.447	template1
2	2rh1_A	5.553	template2
3	2vt4a	5.069	template3
4	1l9ha	4.527	template4
5	3emlA1	2.880	template5
6	3emlA1	8.956	template6
7	2vt4_A	4.577	template7
8	hs1f88	1.210	template8
9	1l9ha	3.498	template9
10	3d4sA1	1.705	template10
(a) Rank of templates represents the top ten threading templates used by GPCR-I-TASSER. (b) Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa. (c) Download Templates provides the 3D structure of the aligned regions of the threading templates.

Reference:

J Zhang, J Yang, R Jang, Y Zhang, Novel hybrid approach to G protein-coupled receptor structure modeling and case study on human genome, submitted, 2014.

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