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This page contains 3D structural models (Version 2,
built on March 2014) of all 1,062 putative G protein-coupled receptors
(GPCRs) in the human genome
generated by the GPCR-I-TASSER
pipeline.
In GPCR-I-TASSER, the GPCR sequences are first threaded through the GPCR template library to
identify muliple structure templates by the LOMETS
programs.
When significant templates are identified, full-length models will be constructed by the
I-TASSER based fragment assembly simulations,
which are assisted by a GPCR and membrane specific force field and spatial restraints collected from
mutagenesis experiments in GPCR-RD.
If there is no significant template hit, an ab initio folding procedure is developed to assemble the
seven transmembrane helix bundle from artificial helices, followed by the I-TASSER based refinment
simulations.
For multiple domain GPCRs, structural models are built by GPCR-I-TASSER for each domain separately
which are then assembly by the I-TASSER approach.
All the models are finally subjected to FG-MD
for fragment-guided molecular dynamic
simulation refinements.
Note:
- For each entry, the GPCR-HGmod data include top-five full-length models, LOMETS template and alignments,
secondary structure prediction, solvent accessibility prediction, and residue-specific error and B-factor
predictions.
- The GPCR-I-TASSER models have generally higher resolution in the transmembrane regions;
users should bear cautions on using the loop and tail regions of the models
which have usually low resolution. Users are encouraged to check the attached
residue-specific quality (RSQ) prediction to
assess the local structure errors.
- All the models were constructed from the GPCR sequence alone. An attachment of addition
ligand molecules may change the conformation of the structures.
- All experimentally solved GPCR structures can be found at
GPCR-EXP Database.
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Other GPCR-related resources
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[
GPCR-HGmod Version 1: Human GPCR structure models generated in Jun 2013 ]
[
GPCR-HGmod Version 2: Human GPCR structure models generated in Mar 2014 ]
[
GPCR-HGmod Version 3: Human GPCR structure models generated in Aug 2014 ]
Structure Models of GPCRs in Human Genome << < 11 12 13 14 15 16 17 18 19 20 > >>
HG ID |
UniProt ID |
Entry Name |
C-score |
Estimated TM-score |
Estimated RMSD |
Top 10 Templates |
HG0420 |
P08172 |
ACM2_HUMAN |
0.2 |
0.74 ± 0.11 |
6.7 ± 4 |
3uon_A,3uon_A,3uonA,3uonA,3uona,3uona,3uonA,3uonA,3uonA,3uonA |
|
HG0421 |
A6NMS3 |
OR5K4_HUMAN |
-0.35 |
0.67 ± 0.13 |
7.1 ± 4.2 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,4grv_A,2ydoa,3emlA1,3emlA1 |
HG0422 |
Q8NGW1 |
OR6B3_HUMAN |
-0.27 |
0.68 ± 0.12 |
7 ± 4.1 |
4iaqA1,3vw7_A,3emlA1,2ydoa,3emlA1,4iaqA1,4grv_A,2ydoa,3emlA1,3emlA1 |
|
HG0423 |
Q1JUL6 |
Q1JUL6_HUMAN |
-0.07 |
0.7 ± 0.12 |
6.5 ± 3.9 |
4iaqA1,3odu_A,3emlA1,2ydoa,2rh1A1,4iaqA1,2rh1_A,3emla,3sn6R,3emlA1 |
HG0424 |
P30542 |
AA1R_HUMAN |
0.8 |
0.82 ± 0.08 |
4.7 ± 3.1 |
3sn6R2,3eml_A,4iaqA1,2ydoa,2rh1A1,3sn6R2,3eml_A,3zpqa,3emlA,3d4sA1 |
|
HG0425 |
Q8NGC6 |
OR4KH_HUMAN |
-0.35 |
0.67 ± 0.13 |
7.1 ± 4.1 |
4iaqA1,3uon_A,3emlA1,1l9ha,3emlA1,3v2wA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
HG0426 |
A0N0W7 |
A0N0W7_HUMAN |
-0.36 |
0.67 ± 0.13 |
7.2 ± 4.2 |
4iaqA1,3odu_A,3emlA1,3vg9a,2rh1A1,4iaqA1,2rh1_A,4eiya,3sn6R,4iaqA1 |
|
HG0427 |
Q8N349 |
OR2LD_HUMAN |
0.17 |
0.74 ± 0.11 |
5.9 ± 3.7 |
3pblA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
HG0428 |
Q8NGB4 |
OR4S1_HUMAN |
-0.15 |
0.69 ± 0.12 |
6.6 ± 4 |
4iaqA1,3uon_A,3emlA1,1l9ha,3emlA1,3v2wA1,3uon_A,2ydoa,3emlA1,3emlA1 |
|
HG0429 |
P51684 |
CCR6_HUMAN |
-1.46 |
0.53 ± 0.15 |
9.99 ± 4.6 |
4mbsA1,3odu_A,4mbsA1,4mbsa,4mbsA1,4mbsA1,3odu_A,4mbsa,4mbsA,4mbsA1 |
HG0430 |
Q8NGQ3 |
OR1S2_HUMAN |
-0.55 |
0.64 ± 0.13 |
7.6 ± 4.3 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
|
HG0431 |
Q8NGN0 |
OR4D5_HUMAN |
-0.22 |
0.68 ± 0.12 |
6.8 ± 4 |
4iaqA1,3uon_A,3emlA1,1l9ha,3emlA1,3v2wA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
HG0432 |
Q9GZK3 |
OR2B2_HUMAN |
-1.15 |
0.57 ± 0.15 |
9.2 ± 4.6 |
3pblA1,2rh1_A,3emlA1,2ydoa,3emlA1,3v2wA1,4grv_A,2ydoa,3emlA1,3emlA1 |
|
HG0433 |
Q96R47 |
O2A14_HUMAN |
-0.13 |
0.7 ± 0.12 |
6.5 ± 4 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
HG0434 |
Q9UN25 |
Q9UN25_HUMAN |
-0.36 |
0.67 ± 0.13 |
7.2 ± 4.2 |
4mbsA,4mbsa,4mbsA,4mbsA,4mbsa,4mbsA1,4mbsA1,4mbsA1,4mbsA1,4mbsA |
|
HG0435 |
A3KFT3 |
OR2M5_HUMAN |
0.05 |
0.72 ± 0.11 |
6.2 ± 3.8 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
HG0436 |
Q8NGQ2 |
OR6Q1_HUMAN |
-0.11 |
0.7 ± 0.12 |
6.5 ± 3.9 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,3v2wA1,4grv_A,2ydoa,3emlA1,3emlA1 |
|
HG0437 |
B0EX00 |
B0EX00_HUMAN |
-1.06 |
0.58 ± 0.14 |
8.9 ± 4.6 |
4mbsA,4mbsA,4mbsa,4mbsA,4mbsa,4mbsA1,4mbsA1,4mbsA1,4mbsA1,4mbsA |
HG0438 |
Q8NGT1 |
OR2K2_HUMAN |
-1.27 |
0.56 ± 0.15 |
9.4 ± 4.6 |
4iaqA1,2rh1_A,3emlA1,2ydoa,3emlA1,2z73A,4grv_A,2ydoa,3emlA1,3emlA1 |
|
HG0439 |
Q86SH1 |
Q86SH1_HUMAN |
-0.38 |
0.66 ± 0.13 |
7.2 ± 4.2 |
4iaqA1,3uon_A,3emlA1,1l9ha,3emlA1,4iaqA1,4grv_A,2ydoa,3emlA1,3emlA1 |
HG0440 |
O14843 |
FFAR3_HUMAN |
-1.27 |
0.56 ± 0.15 |
9.4 ± 4.6 |
4mbsA1,3vw7_A,4mbsA1,4ea3a,4mbsA1,4mbsA1,3vw7_A,4ea3a,3vw7A,4mbsA1 |
|
HG0441 |
Q86SH3 |
Q86SH3_HUMAN |
-0.52 |
0.65 ± 0.13 |
7.5 ± 4.3 |
4iaqA1,3uon_A,3emlA1,1l9ha,3emlA1,4iaqA1,4grv_A,2ydoa,3emlA1,3emlA1 |
HG0442 |
Q8NGS8 |
O13C5_HUMAN |
-0.34 |
0.67 ± 0.13 |
7.1 ± 4.1 |
3pblA1,3uon_A,3emlA1,2ydoa,3emlA1,3sn6R2,4grv_A,2ydoa,3emlA1,3emlA1 |
|
HG0443 |
Q8NHC4 |
O10J5_HUMAN |
-0.04 |
0.71 ± 0.12 |
6.3 ± 3.9 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,3vw7_A,2ydoa,3emlA1,3emlA1 |
HG0444 |
Q8NGJ5 |
O51L1_HUMAN |
-0.24 |
0.68 ± 0.12 |
6.8 ± 4.1 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,3uonA1,2rh1_A,4gpoa,3emlA1,3emlA1 |
|
HG0445 |
B9EIM0 |
B9EIM0_HUMAN |
0.15 |
0.73 ± 0.11 |
6 ± 3.7 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
HG0446 |
Q8NGD4 |
OR4K1_HUMAN |
-0.21 |
0.69 ± 0.12 |
6.7 ± 4 |
4iaqA1,3uon_A,3emlA1,1l9ha,3emlA1,3v2wA1,2rh1_A,2ydoa,3emlA1,3emlA1 |
|
HG0447 |
O95221 |
OR5F1_HUMAN |
-0.01 |
0.71 ± 0.11 |
6.3 ± 3.9 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,4grv_A,2ydoa,3emlA1,3emlA1 |
HG0448 |
P30411 |
BKRB2_HUMAN |
-1.66 |
0.51 ± 0.15 |
9.99 ± 4.6 |
4mbsA1,3odu_A,4mbsA1,4mbsa,4mbsA1,4mbsA1,3odu_A,4mbsa,4mbsA,4mbsA1 |
|
HG0449 |
Q8NH87 |
OR9G1_HUMAN |
-0.18 |
0.69 ± 0.12 |
6.6 ± 4 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,4iaqA1,4grv_A,2ydoa,3emlA1,3emlA1 |
HG0450 |
A2RRF6 |
A2RRF6_HUMAN |
-0.2 |
0.69 ± 0.12 |
6.7 ± 4 |
4iaqA1,3uon_A,3emlA1,2ydoa,3emlA1,3v2wA1,3vw7_A,2ydoa,3emlA1,3emlA1 |
Reference:
J Zhang, J Yang, R Jang, Y Zhang.
Hybrid structure modeling of G protein-coupled receptors in the human
genome.
submitted (2015).
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