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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Senktide
Molecular formula	C40H55N7O11S
IUPAC name	(3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(3-carboxypropanoylamino)-4-oxobutanoic acid
Molecular weight	841.978
Hydrogen bond acceptor	12
Hydrogen bond donor	8
XlogP	1.1
Synonyms	CS-8091 MolPort-044-561-362 suc[Asp6,MePhe3]SP(6-11) 4-10-Neuromedin B (swine spinal cord), N-(3-carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine- AKOS027301460 GTPL2127 SCHEMBL5238634 (3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[(4-hydroxy-4-oxobutanoyl)amino]-4-o L-Methioninamide, N-(3-carboxy-1-oxopropyl)-L-alpha-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl- Substance P (6-11), succinyl-aspartyl(6)-methylphenylalanine(8)- 189261-10-7 CTK8E9092 N-(3-Carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-4-10-neuromedin B (swine spinal cord) suc[Asp6,MePhe3]SP(6-11)) B6580 HY-P0187 (5S,8S,14S,17S,20S)-14,17-Dibenzyl-5-carbamoyl-20-(carboxymethyl)-8-isobutyl-15-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-25-oic acid CHEMBL106124 LS-96168 Succinyl-6-asp-8-Me-phe-substance P (6-11) AC1L33FH D05ZWG RT-015687 ZINC95615286 BDBM50052524 J-001543 Substance P (6-11), succinyl-asp(6)-Me-phe(8)- (S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-3-(3-carboxy-propionylamino)-succinamic acid [ Show all ]
Inchi Key	HMHYXLVEFVGOPM-QKUYTOGTSA-N
Inchi ID	InChI=1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1
PubChem CID	108147
ChEMBL	CHEMBL106124
IUPHAR	2127
BindingDB	50052524
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
118617	Neuromedin-K receptor	P16177	Tacr3	Rattus norvegicus (Rat)	452
118619	Neuromedin-K receptor	P29371	TACR3	Homo sapiens (Human)	465
118622	Neuromedin-K receptor	P30098	TACR3	Cavia porcellus (Guinea pig)	440
553870	Neuromedin-K receptor	P47937	Tacr3	Mus musculus (Mouse)	452
118620	Substance-K receptor	P16610	Tacr2	Rattus norvegicus (Rat)	390
446368	Substance-K receptor	P21452	TACR2	Homo sapiens (Human)	398
118621	Substance-P receptor	P25103	TACR1	Homo sapiens (Human)	407
118623	Substance-P receptor	P30547	TACR1	Cavia porcellus (Guinea pig)	407

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