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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Clothiapine
Molecular formula	C18H18ClN3S
IUPAC name	8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
Molecular weight	343.873
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.6
Synonyms	AC1L27RX BRD-K10990317-001-02-9 Clotiapine DIBENZO(b,f)(1,4)THIAZEPINE, 2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)- Entumin (TN) KAAZGXDPUNNEFN-UHFFFAOYSA-N PDSP1_000469 UNII-Z05HCY0X1T 2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine(clothiapine) 2058-52-8 BCP06511 C18H18ClN3S Clothiapine (USAN) Clotiapinum DSSTox_GSID_22851 FT-0603194 MRF-0000024 SCHEMBL122941 ZINC26185346 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine BPBio1_001137 CHEBI:108591 Clotiapina D01597 EINECS 218-162-8 HMS2089L15 NCGC00160387-03 Tox21_111779 2-chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]thiazepine 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine AKOS005065858 BRN 0568276 CHEMBL304902 Clotiapine (JAN/INN) Dibenzo[b,f][1,4]thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)- Entumine LS-61278 PDSP2_000467 W 130 BDBM50040237 CAS-2058-52-8 Clothiapine [USAN:BAN] Clotiapinum [INN-Latin] DSSTox_RID_76758 HF 2159 NCGC00160387-01 SR-05000001467 (E)-2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine AB01275460-01 BRD-K10990317-001-01-1 CHEBI:31424 Clotiapina [INN-Spanish] D0PX8L Entumin J-013441 NCGC00160387-04 Tox21_111779_1 2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)thiazepine AN-16597 C-20429 Clotiapine [INN] DSSTox_CID_2851 Etumine LW 2159 S-805C Z05HCY0X1T 8-chloro-6-(4-methyl-1-piperazinyl)benzo[b][1,4]benzothiazepine Biomol-NT_000008 CC-25941 Clothiapine [USAN] CTK8F8741 DTXSID5022851 HF-2159 NCGC00160387-02 SR-05000001467-1 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine [ Show all ]
Inchi Key	KAAZGXDPUNNEFN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
PubChem CID	16351
ChEMBL	CHEMBL304902
IUPHAR	N/A
BindingDB	50040237
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
556125	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
164173	5-hydroxytryptamine receptor 6	P31388	Htr6	Rattus norvegicus (Rat)	436
556124	5-hydroxytryptamine receptor 7	P32305	Htr7	Rattus norvegicus (Rat)	448
164174	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
164172	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
460687	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443

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