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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Nafadotride
Molecular formula	C22H27N3O2
IUPAC name	N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide
Molecular weight	365.477
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.0
Synonyms	CHEBI:64191 FT-0643448 KB-125336 N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE SR-01000597572 AKOS024257976 CPD000466292 HMS2232B11 LS-187623 BRD-A71262238-001-04-3 DB-043003 HMS3394A15 MolPort-023-276-076 SCHEMBL635866 4-Cyano-1-methoxy-naphthalene-2-carboxylic acid (1-butyl-pyrrolidin-2-ylmethyl)-amide GTPL44 L000428 N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-Methoxy-2naphthalenecarboxamide SR-01000597572-1 A1-01951 BCP27779 CTK8H0240 HMS3267P15 MLS000758952 NC00369 (+-)-nafadotride CCG-101119 DTXSID1042603 J-008605 N-((1-butylpyrrolidin-2-yl)methyl)-4-cyano-1-methoxy-2-naphthamide SMR000466292 CHEMBL286252 HMS2052A15 LS-186981 N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide TRA0072321 AC1MPBUT BDBM50133923 D0W1HM HMS3370D02 MLS001424218 SAM001247092 149649-22-9 [ Show all ]
Inchi Key	IDZASIQMRGPBCQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)
PubChem CID	3408722
ChEMBL	CHEMBL286252
IUPHAR	44
BindingDB	50133923
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
553942	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
130941	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
553944	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
130937	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
553943	D(4) dopamine receptor	P30729	Drd4	Rattus norvegicus (Rat)	387

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