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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	riluzole
Molecular formula	C8H5F3N2OS
IUPAC name	6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
Molecular weight	234.196
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.6
Synonyms	Riluzolum SC-18839 ST038494 Tox21_110252_1 ZINC6481 Riluzole (Rilutek) BRD-K21283037-003-06-2 Prestwick2_000167 CHEMBL744 Riluzol [INN-Spanish] DB00740 2-amino-6-(trifluoromethoxy)-1,3-benzothiazole FT-0082997 2-amino-6-trifluoromethoxybenzothiazole HMS3263E10 6-(trifluoromethoxy)benzothiazol-2-amine KS-00000W6R 744R225 MLS000069369 AC1Q530H NCGC00015882-07 ANW-22711 NCGC00023141-02 Bio1_000416 NSC759823 RP-54274 SMR000058231 STK503686 UNII-7LJ087RS6F Riluzole [USAN:USP:INN:BAN] C8H5F3N2OS R-116 CS-2156 DSSTox_RID_80739 2-amino-6-(trifluoromethoxy)benzo[d]thiazole GTPL2326 HY-B0211 6-trifluoromethoxy-1,3-benzothiazol-2-ylamine Lopac0_001064 A13951 NCGC00015882-02 AKOS000265071 NCGC00015882-10 BCP02142 NCGC00023141-06 Biomol-NT_000245 PK-26124 SBB012436 Spectrum2_000550 Tocris-0768 ZB000641 Riluzole, solid Prestwick0_000167 CHEBI:8863 Rilutek\|\|\|Rilutor\|\|\|6-(Trifluoromethoxy)-2-benzothiazolamine D0H0KB 1744-22-5 EU-0101064 2-Amino-6-trifluoro-methoxybenzothiazole HMS2094G07 6-(Trifluoromethoxy)-2-amino-benzothiazole J10441 6-trifluoromethoxybenzothiazole-2-yl-amine MCULE-9362288181 AC-730 NCGC00015882-05 Amino-2 trifluoromethoxy-6 benzothiazole [French] NCGC00015882-13 BF-37 NSC-759823 BRD-K21283037-001-02-5 Riluzolum [INN-Latin] SC-64630 ST068834 Tox21_501064 Riluzole HCl BSPBio_000033 Prestwick3_000167 cid_5070 DSSTox_CID_25192 2-Amino-6-(trifluoromethoxy)-benzothiazole FT-0611194 2-Benzothiazolamine, 6-(trifluoromethoxy)- HMS3371A09 6-(trifluoromethoxy)benzothiazole-2-ylamine KS-5231 7LJ087RS6F MolPort-000-151-262 ACMC-209e89 NCGC00015882-08 BBL013272 NCGC00023141-04 Bio1_000905 Opera_ID_548 RP28111 SPBio_000599 SW196805-4 VU0239571-11 Riluzole(Rilutek)/ PK-26124, RP-54274, Rilutek, Riluzole CAS-1744-22-5 Rilutek CTK4D4982 DTXSID3045192 2-amino-6-(trifluoromethoxyl)benzothiazole HMS1773G08 4CA-1092 I01-2084 6-trifluoromethoxy-2-amino-benzothiazole LP01064 AB0012884 NCGC00015882-03 ALBB-006046 NCGC00015882-11 BDBM30705 NCGC00261749-01 BPBio1_000037 Riluzole, United States Pharmacopeia (USP) Reference Standard SBI-0051034.P002 SR-01000002997-3 Tox21_110252 ZERO/001785 Riluzole (JAN/USAN/INN) Prestwick1_000167 Riluzol DB-030335 2-Amino-6-(Trifluoromethoxy) Benzothiazole F3282-0020 2-amino-6-trifluoromethoxy-benzothiazole HMS2233E14 6-(trifluoromethoxy)-2-aminobenzothiazole KB-20157 6-trifluoromethoxybenzo[d]thiazol-2-amine MFCD00210213 AC1L1JJL NCGC00015882-06 AN-6550 NCGC00015882-15 BIDD:GT0055 NSC753433 BRD-K21283037-003-03-9 RP 54274 SCHEMBL78905 ST24029598 TR-007739 Riluzole [USAN:INN] C07937 PubChem14501 CJ-00110 DSSTox_GSID_45192 2-Amino-6-(trifluoromethoxy)benzothiazole FTALBRSUTCGOEG-UHFFFAOYSA-N 2-Benzothiazolamine,6-(trifluoromethoxy)- HMS3657E13 6-(trifluoromethoxy)benzo[d]thiazol-2-amine Lopac-R-116 A-5766 NCGC00015882-01 AJ-08278 NCGC00015882-09 BC219019 NCGC00023141-05 Bio1_001394 Pharmakon1600-01505348 s1614 SPBio_001954 Tiglutik (thickened oral suspension) Z166605314 Riluzole, 98% Prestwick-03A08 CCG-39528 Rilutek (TN) D00775 EN300-23782 2-Amino-6-trifluoro- methoxybenzothiazole HMS2089O19 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine J10184 6-Trifluoromethoxy-benzothiazol-2-ylamine LS-40688 ABP000632 NCGC00015882-04 Amino-2 trifluoromethoxy-6 benzothiazole NCGC00015882-12 BENZOTHIAZOLE, 2-AMINO-6-TRIFLUOROMETHOXY- NSC-753433 BPBio1_000837 [ Show all ]
Inchi Key	FTALBRSUTCGOEG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
PubChem CID	5070
ChEMBL	CHEMBL744
IUPHAR	N/A
BindingDB	30705
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
86552	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
86554	5-hydroxytryptamine receptor 2A	P35363	Htr2a	Mus musculus (Mouse)	471
86553	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400

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