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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	TAK-875
Molecular formula	C29H32O7S
IUPAC name	2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid
Molecular weight	524.628
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	4.7
Synonyms	cc-64 Fasiglifam KS-00001CRE RL00413 X7587 3-Benzofuranacetic acid, 6-[[2',6'-diMethyl-4'-[3-(Methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]Methoxy]-2,3-dihydro-, (3S)- AK170559 AT-35664 CS-0282 GLP1W4JXAH PB24359 TAK 875 [(3s)-6-({2',6'-Dimethyl-4'-[3-(Methylsulfonyl)propoxy]biphenyl-3-Yl}methoxy)-2,3-Dihydro-1-Benzofuran-3-Yl]acetic Acid (S)-2-(6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid BZCALJIHZVNMGJ-HSZRJFAPSA-N DB12491 J-501277 QCR-231 TAK875 2-[(3S)-6-({3-[4-(3-methanesulfonylpropoxy)-2,6-dimethylphenyl]phenyl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid ABP000968 Fasiglifam (INN) MolPort-023-293-501 SC-86271 ZINC68208039 ((3S)-6-((3-(4-(3-Methanesulfonylpropoxy)-2,6-dimethylphenyl]phenyl}methoxy)-2,3-dihydro-1-benzofuran-3-yl)acetic acid 4phu AKOS025289552 BCP02430 D0V1WQ GTPL6484 PubChem24441 [(3S)-6-({3-[4-(3-methanesulfonylpropoxy)-2,6-dimethylphenyl]phenyl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid 1000413-72-8 A8339 C29H32O7S EX-A203 KB-80796 RL00005 UNII-GLP1W4JXAH 2YB AC-25651 CHEMBL1829174 Fasiglifam [USAN:INN] NCGC00346669-01 SCHEMBL204652 [(3S)-6-([2',6'-DIMETHYL-4'-[3-(METHYLSULFONYL)PROPOXY]BIPHENYL-3-YL]METHOXY)-2,3-DIHYDRO-1-BENZOFURAN-3-YL]ACETIC ACID (3S)-6-[[2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid AOB2992 BDBM50386790 D10336 HY-10480 Q-4156 TAK-875(Fasiglifam) 1000413-72-8 , TAK875 , TAK 875 AB0033816 [ Show all ]
Inchi Key	BZCALJIHZVNMGJ-HSZRJFAPSA-N
Inchi ID	InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1
PubChem CID	24857286
ChEMBL	CHEMBL1829174
IUPHAR	6484
BindingDB	50386790
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
36309	Free fatty acid receptor 1	O14842	FFAR1	Homo sapiens (Human)	300
36311	Free fatty acid receptor 1	Q8K3T4	Ffar1	Rattus norvegicus (Rat)	300
36312	Free fatty acid receptor 2	O15552	FFAR2	Homo sapiens (Human)	330
36308	Free fatty acid receptor 3	O14843	FFAR3	Homo sapiens (Human)	346
36310	Free fatty acid receptor 4	Q5NUL3	FFAR4	Homo sapiens (Human)	377
558389	Melanocortin receptor 4	P70596	Mc4r	Rattus norvegicus (Rat)	332

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