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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	xylazine
Molecular formula	C12H16N2S
IUPAC name	N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Molecular weight	220.334
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.8
Synonyms	4H-1,3-Thiazin-2-amine,N-(2,6-dimethylphenyl)-5,6-dihydro- Lopac0_001249 AB00052246-13 NCGC00016098-01 AJ-08151 NCGC00016098-09 BC252840 NSC758142 BRD-K21565985-001-05-0 Primazine CHEBI:92386 Sedomin DivK1c_000449 Spectrum4_000239 HMS1569H18 HMS501G11 2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine KBio3_002523 Xylazine [USAN:INN:BAN] TRA0042707 Xylasol KM1558 4H-1,3-Thiazine-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro- (9CI) MLS000054617 AB00052246_17 NCGC00016098-04 Anased NCGC00038586-03 BCP0726000235 Prestwick0_000598 BSPBio_003023 Rompun (Salt/Mix) CS-2549 SPBio_001315 DSSTox_RID_79519 SR-01000075296 HMS2092L07 (5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-amine IDI1_000449 23076-35-9 (mono-hydrochloride) Xylazine, >=99% X5891 Xylazin 361X617 L001033 N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine AC-22589 NCGC00016098-07 BAY-VA-1470 NINDS_000449 BPBio1_000524 Prestwick3_000598 CCG-39193 SC-47279 D0Y2JI Spectrum2_001448 FT-0654963 HMS3369L20 2,6-Xylidine, N-(5,6-dihydro-4H-1,3-thiazinyl)- KBio2_004315 Xylazine (USP/INN) Xylzin Tox21_110303 Xylapan KBioGR_000937 4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)- LS-150494 AB00052246-15 NCGC00016098-02 AK117805 NCGC00016098-11 BCBcMAP01_000167 Opera_ID_1260 BRD-K21565985-001-15-9 Rometar SMP1_000319 DSSTox_CID_20643 Spectrum5_001250 HMS1921P17 (2,6-Dimethyl-phenyl)-[1,3]thiazinan-2-ylidene-amine HY-B0443 2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride Xylazine [USP:INN:BAN] UNII-2KFG9TP5V8 Xylasol (Salt/Mix) KS-00000H9L 5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazine MLS000881122 AB00052246_18 NCGC00016098-05 AS-54468 NCGC00038586-04 BDBM50027069 Prestwick1_000598 C-46044 SBB038475 CTK5D8365 SPBio_002695 DTXSID3040643 HMS2096H18 (5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-amine;N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine KBio1_000449 29335-81-7 Xylazinum SR-01000075296-4 Xilazina 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro- Lopac-X-1251 7361-61-7 Narcoxyl AC1L1KYH NCGC00016098-08 Bayer 1470 NSC-758142 BPICBUSOMSTKRF-UHFFFAOYSA-N Prestwick_962 Chanazine (TN) SCHEMBL15487 Spectrum3_001472 GTPL523 HMS3713H18 2-(2,6-Dimethylanilino)-5,6-dihydro-4H-1,3-thiazine KBio2_006883 xylazine free base ZINC2248 Tox21_110303_1 Xylapan (Salt/Mix) KBioSS_001747 4H-1,3-Thiazine-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro- MFCD00057908 AB00052246-16 NCGC00016098-03 AKOS000115960 NCGC00038586-02 BCP03045 Pharmakon1600-01501200 BSPBio_000476 Rompun CHEMBL297362 SMR000061135 DSSTox_GSID_40643 Spectrum_001267 HMS2089E20 (2,6-dimethylphenyl)-4,5-dihydro-6H-1,3-thiazin-2-ylamine I06-1056 2-[2,6-Dimethylphenylamino]-4H-5,6-dihydroxthiazine Xylazine(Rompun) WH 7286 Xylaxine 2KFG9TP5V8 KSC638G6L MolPort-000-869-370 AB2000618 NCGC00016098-06 BAY 1470 NCGC00038586-05 BDBM50225286 Prestwick2_000598 CAS-7361-61-7 SBI-0051216.P003 D08683 SPECTRUM1501200 EINECS 230-902-1 HMS2232F24 KBio2_001747 Xylazine (free base) Xylazinum [INN-Latin] SR-01000075296-6 Xilazina [INN-Spanish] [ Show all ]
Inchi Key	BPICBUSOMSTKRF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
PubChem CID	5707
ChEMBL	CHEMBL297362
IUPHAR	523
BindingDB	50027069
DrugBank	DB11477
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
29579	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
29582	Alpha-2A adrenergic receptor	P18871	ADRA2A	Sus scrofa (Pig)	450
29585	Alpha-2A adrenergic receptor	Q01338	Adra2a	Mus musculus (Mouse)	450
29583	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
29580	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
29581	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
29584	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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