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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	ISOLOXAPINE
Molecular formula	C18H18ClN3O
IUPAC name	3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
Molecular weight	327.812
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.1
Synonyms	8-Chloro-11-(4-methyl-piperazin-1-yl)dibenzo[b,f][1,4]oxazepine LS-61561 BDBM50028980 D0Q2GP 8-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine SCHEMBL2738975 8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine AWHNHDGHHNGACT-UHFFFAOYSA-N 3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine CHEMBL7828 [ Show all ]
Inchi Key	AWHNHDGHHNGACT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3
PubChem CID	10381810
ChEMBL	CHEMBL7828
IUPHAR	N/A
BindingDB	50028980
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
16033	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
16037	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
16038	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
16034	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
16035	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
16036	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
16032	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390

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