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You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Extracellular calcium-sensing receptor
Species	Rattus norvegicus (Rat)
Gene	Casr
Synonym	PCaR1 Parathyroid cell calcium-sensing receptor GPRC2A extracellular calcium-sensing receptor divalent cation-sensing receptor CaSR CaS receptor CaR calcium-sensing receptor RaKCaR {ECO:0000303\|PubMed:7816802} [ Show all ]
Disease	N/A for non-human GPCRs
Length	1079
Amino acid sequence	MASYSCCLALLALAWHSSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPSLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQYKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAWASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIAKEIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQILICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKVYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSSSLGGSTGSIPSSSISSKSNSEDRFPQPERQKQQQPLSLTQQEQQQQPLTLHPQQQQQPQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSMRQNSLEAQRSNDTLGRHQALLPLQCADADSEMTIQETGLQGPMVGDHQPEMESSDEMSPALVMSTSRSFVISGGGSSVTENVLHS
UniProt	P48442
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2516
IUPHAR	54
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
441834	CHEMBL539091	C26H33ClN2O4S	505.07	6 / 3	N/A	No
521540	CHEMBL3752041	C17H18N2	250.345	1 / 2	3.3	Yes
4014	CHEMBL1801168	C26H25ClN2O2S	465.008	4 / 3	N/A	N/A
4015	CHEMBL1801169	C26H25ClN2O2S	465.008	4 / 3	N/A	N/A
4903	CHEMBL534719	C27H30ClN3O	448.007	2 / 4	N/A	N/A
7769	CHEMBL559185	C25H30N2O3S	438.586	5 / 2	4.9	Yes
521677	CHEMBL3753240	C28H26N2O	406.529	2 / 2	6.1	No
521892	CHEMBL3753132	C17H17BrN2	329.241	1 / 2	4.0	Yes
522024	CHEMBL3753704	C22H22N2O	330.431	2 / 2	4.6	Yes
20921	CHEMBL556205	C29H33ClN2O4S	541.103	6 / 3	N/A	No
465580	CHEMBL3633665	C23H27N3O2	377.488	4 / 1	3.1	Yes
522225	CHEMBL3752334	C23H24N2O2	360.457	3 / 2	4.5	Yes
26837	CHEMBL553089	C29H29ClN2O4S	537.071	5 / 2	N/A	No
522555	CHEMBL3752128	C23H22N2	326.443	1 / 2	5.0	Yes
33787	CHEMBL539510	C29H33ClN2O4S	541.103	6 / 3	N/A	No
34629	CHEMBL544753	C28H31ClN2O3S	511.077	5 / 3	N/A	No
40264	CHEMBL543640	C21H19ClN2O	350.846	1 / 3	N/A	N/A
40327	CHEMBL536974	C24H26Cl4N2O2S	548.344	4 / 3	N/A	No
522796	CHEMBL3754606	C21H20N2O	316.404	2 / 3	4.2	Yes
523147	CHEMBL3752546	C17H18N2O	266.344	2 / 3	3.5	Yes
61067	CHEMBL554406	C28H31ClN2O2S	495.078	4 / 3	N/A	N/A
62283	CHEMBL1801171	C21H23ClN2O3S	418.936	5 / 3	N/A	N/A
64286	CHEMBL536976	C24H27Cl3N2O2S	513.902	4 / 3	N/A	No
64818	CHEMBL536513	C24H28ClN3O4S	490.015	6 / 3	N/A	N/A
66261	CHEMBL555417	C25H31ClN2O3S	475.044	5 / 3	N/A	N/A
69518	CHEMBL536975	C26H28ClF3N2O2	492.967	6 / 3	N/A	N/A
69519	CHEMBL557567	C26H28ClF3N2O2	492.967	6 / 3	N/A	N/A
69520	CHEMBL558962	C26H28ClF3N2O2	492.967	6 / 3	N/A	N/A
69521	CHEMBL556781	C26H28ClF3N2O2	492.967	6 / 3	N/A	N/A
523607	CHEMBL3752914	C18H20N2O	280.371	2 / 2	3.3	Yes
78731	CHEMBL545444	C27H29ClN2O2S	481.051	4 / 3	N/A	N/A
523828	CHEMBL3752605	C22H22N2O2S	378.49	3 / 2	3.8	Yes
523837	CHEMBL3753180	C24H24N2	340.47	1 / 2	5.4	No
472839	CHEMBL3633663	C26H29N3O3	431.536	4 / 1	3.0	Yes
84771	Ronacaleret	C25H31F2NO4	447.523	7 / 3	1.7	Yes
473500	CHEMBL3633650	C23H25N3O3	391.471	4 / 1	2.6	Yes
86971	CHEMBL537427	C25H28ClF3N2O3S	529.015	8 / 3	N/A	No
86972	CHEMBL537426	C25H28ClF3N2O3S	529.015	8 / 3	N/A	No
86973	CHEMBL539852	C25H28ClF3N2O3S	529.015	8 / 3	N/A	No
86974	CHEMBL539087	C25H28ClF3N2O3S	529.015	8 / 3	N/A	No
101344	CHEMBL1801170	C21H23ClN2O3S	418.936	5 / 3	N/A	N/A
107677	CHEMBL543637	C29H33ClN2O	461.046	3 / 3	N/A	N/A
110225	CHEMBL539608	C24H28Cl2N2O2S	479.46	4 / 3	N/A	N/A
553806	CHEMBL200312	C26H31N3OS	433.614	5 / 2	4.6	Yes
524851	CHEMBL3753320	C21H19FN2	318.395	2 / 2	4.7	Yes
120543	CHEMBL559185	C25H31ClN2O3S	475.044	5 / 3	N/A	N/A
132888	CHEMBL534941	C25H29ClN2O2	424.969	3 / 3	N/A	N/A
133537	CHEMBL558961	C25H28ClF3N2O2S	513.016	7 / 3	N/A	No
525650	CHEMBL3753595	C21H20N2O	316.404	2 / 3	4.2	Yes
149910	CHEMBL552669	C28H30Cl2N2	465.462	2 / 3	N/A	N/A
525844	CHEMBL3753550	C21H19N3O2	345.402	3 / 2	4.4	Yes
153144	CHEMBL199495	C27H33FN2O2	436.571	5 / 3	4.8	Yes
153853	calindol	C21H20N2	300.405	1 / 2	4.6	Yes
153856	CHEMBL543875	C21H20N2	300.405	1 / 2	4.6	Yes
526010	CHEMBL3752122	C27H24N2	376.503	1 / 2	6.2	No
167764	CHEMBL1788292	C21H21ClN2	336.863	1 / 3	N/A	N/A
167765	ent-Calindol Hydrochloride	C21H21ClN2	336.863	1 / 3	N/A	N/A
167767	Calindol Hydrochloride	C21H21ClN2	336.863	1 / 3	N/A	N/A
169413	CHEMBL559160	C26H30ClN3O4S	516.053	6 / 3	N/A	No
172987	CHEMBL541075	C28H30Cl2N2	465.462	2 / 3	N/A	N/A
175905	CHEMBL1203923	C23H26ClN3O4S	475.988	6 / 3	N/A	N/A
182037	CHEMBL539341	C25H28Cl2N2O	443.412	2 / 3	N/A	N/A
188835	CHEMBL541541	C23H28ClN3O2S	446.006	5 / 4	N/A	N/A
486973	CHEMBL3633656	C24H27N3O4	421.497	5 / 1	2.6	Yes
202756	CHEMBL556364	C24H28ClN3O	409.958	3 / 3	N/A	N/A
206401	CHEMBL543638	C30H35ClN2O2	491.072	4 / 3	N/A	N/A
527602	CHEMBL3752630	C24H26N2O3	390.483	4 / 2	4.5	Yes
219607	CHEMBL553846	C21H20Cl2N2	371.305	1 / 3	N/A	N/A
220014	CHEMBL1801167	C22H25ClN2O2S	416.964	4 / 3	N/A	N/A
527855	CHEMBL3754360	C17H17FN2	268.335	2 / 2	3.4	Yes
221492	CHEMBL552612	C21H20ClFN2	354.853	2 / 3	N/A	N/A
229114	CHEMBL534718	C25H29ClN2O	408.97	2 / 3	N/A	N/A
250132	CHEMBL538740	C28H30Cl2N2O3S	545.519	5 / 3	N/A	No
254694	CHEMBL537870	C25H27Cl3N2O	477.854	2 / 3	N/A	N/A
254695	CHEMBL539089	C25H27Cl3N2O	477.854	2 / 3	N/A	N/A
528812	CHEMBL3753325	C21H19BrN2	379.301	1 / 2	5.3	No
258436	CHEMBL534946	C24H28ClN3O4S	490.015	6 / 3	N/A	N/A
554559	Framycetin	C23H46N6O13	614.65	19 / 13	-9.0	No
263771	CHEMBL537870	C25H26Cl2N2O	441.396	2 / 2	6.5	No
266496	CHEMBL541298	C25H31ClN2O4S	491.043	6 / 3	N/A	N/A
272984	NPS-2143	C24H25ClN2O2	408.926	4 / 2	5.0	Yes
529871	CHEMBL3751914	C22H22N2O	330.431	2 / 2	4.6	Yes
296776	CHEMBL555170	C22H23ClN2	350.89	1 / 2	N/A	N/A
530052	CHEMBL3754639	C21H20N2O	316.404	2 / 3	4.2	Yes
307016	CHEMBL542386	C27H28Cl2N2O2S	515.493	4 / 3	N/A	No
530181	CHEMBL3753832	C18H20N2	264.372	1 / 2	3.7	Yes
307630	CHEMBL543812	C23H26ClN3O4S	475.988	6 / 3	N/A	N/A
308408	CHEMBL557001	C24H29ClN2O2S	445.018	4 / 3	N/A	N/A
311507	CHEMBL539505	C27H28ClN3O4S	526.048	6 / 3	N/A	No
318684	CHEMBL539340	C25H28ClF3N2O2S	513.016	7 / 3	N/A	No
320075	CHEMBL554945	C28H31ClN2	431.02	2 / 3	N/A	N/A
327368	CHEMBL540566	C23H25ClN2O2	396.915	3 / 3	N/A	N/A
332419	CHEMBL1801357	C20H21ClN2O2S	388.91	4 / 3	N/A	N/A
333190	CHEMBL555579	C27H28Cl2N2O2S	515.493	4 / 3	N/A	No
335395	CHEMBL1801166	C21H23ClN2O2S	402.937	4 / 3	N/A	N/A
341421	CHEMBL537205	C25H28Cl2N2O	443.412	2 / 3	N/A	N/A
345727	CHEMBL544579	C22H23ClN2O	366.889	2 / 3	N/A	N/A
350400	CHEMBL553996	C29H31ClN2O5S	555.086	7 / 3	N/A	No
350737	CHEMBL539090	C26H28ClF3N2O	476.968	5 / 3	N/A	N/A
531482	CHEMBL3753306	C21H19N3O2	345.402	3 / 2	4.4	Yes

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