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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	protirelin
Molecular formula	C16H22N6O4
IUPAC name	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	362.39
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	-2.5
Synonyms	HY-P0002 MolPort-006-124-300 Protirelin acetate (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Protirelinum 11096-37-0 s4680 305T279 Synthetic TRH A-38579 Thyroliberin C16H22N6O4 Thyrotropin releasing hormone D00176 TRH DTXSID0023533 ZINC4096261 L-Pyroglutamyl-L-histidinyl-L-prolinamide PR-546 Protirelin, European Pharmacopoeia (EP) Reference Standard (Pyro)-L-glutamic acid-L-histidine-L-proline-NH2 pyroglutamyl-histidyl-prolinamide 2-Pyrrolidinecarboxamide, N-[1-[(2-Carbamoyl-1-pyrrolidinyl)carbonyl]-2-imidazol-4-ylethyl]-5-oxo-, (S,S,S)- Stimu-TSH Thypinone ABBOTT-38579 Thyrotrophin releasing hormone CHEBI:35940 Thyrotropin-releasing factor TSH-releasing factor FT-0638410 L-Pyroglutamyl-L-histidyl-L-prolineamide (2S)-N-[(1S)-2-[(2S)-2-carbamoylpyrrolidino]-1-(1H-imidazol-5-ylmethyl)-2-keto-ethyl]-5-keto-pyrrolidine-2-carboxamide Protireline 1-(3-(1H-Imidazol-5-yl)-2-([(5-oxo-2-pyrrolidinyl)carbonyl]amino)propanoyl)-2-pyrrolidinecarboxamide # Rifathyroin 22365-17-9 Synthetic thyrotropin-releasing hormone 77666-61-6 Thyroid releasing hormone BDBM50072394 Thyrotropic releasing hormone CP-236 Tox21_111939 DSSTox_GSID_23533 UNII-5Y5F15120W Hirtonin KS-00002WUW NCGC00160616-01 Protirelin tartrate (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Protirelinum [INN-Latin] 117217-40-0 SCHEMBL19825647 39422-15-6 Synthetic tsh-releasing factor AB0011512 Thyrothropin relasing hormone CAS-24305-27-9 Thyrotropin releasing hormone, >=98% (HPLC), powder D08BTB trh-sr EINECS 246-143-4 L-Pyroglutamyl-L-histidyl-L-prolinamide Prolinamide, 1-[N-(5-oxo-L-prolyl)-L-histidyl]-, L- Protirelina (S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide Relefact TRH (TN) Synthetic thyrotopin releasing factor 53935-32-3 (1:1 tartrate) Thyrefact AC1LCWUZ Thyrotropic hormone-releasing factor Thyrotropin-releasing factor (pig) DB09421 TSH-releasing hormone FT-0639185 HS-2023 Lopremone Protirelin (JP17/USAN/INN) (2S)-N-[(2S)-1-[(2S)-2-aminocarbonylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxidanylidene-propan-2-yl]-5-oxidanylidene-pyrrolidine-2-carboxamide Protireline [INN-French] 1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide Ro 8-6270/9 24305-27-9 Synthetic TRF 9015-91-2 Thyroid-stimulating hormone-releasing factor C03958 Thyrotropic-releasing factor CS-7080 TRF DSSTox_RID_77067 XNSAINXGIQZQOO-SRVKXCTJSA-N L-Prolinamide, 5-oxo-L-prolyl-L-histidyl- PR 546 Protirelin [USAN:INN:BAN:JAN] (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide PyroGlu-His-prolinamide 2-Pyrrolidinecarboxamide, N-[1-[(2-carbamoyl-1-pyrrolidinyl)carbonyl]-2-imidazol-4-ylethyl]-5-oxo-, SCHEMBL33419 5-Oxo-L-prolyl-L-histidyl-L-prolinamide Synthetic tsh-releasing hormone Abbott 38579 Thyrotrophic hormone releasing hormone CCRIS 2593 Thyrotropin releasing hormone, powder, gamma-irradiated, cell culture tested D0E9TD TRH-SR, Takeda FDA 1725 L-Pyroglutamyl-L-histidyl-L-proline amide Prolinamide, 5-oxo-L-prolyl-L-histidyl-, L- Protirelina [INN-Spanish] (S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide Relefact-TRH 22365-02-2 Synthetic thyrotropin-releasing factor 5Y5F15120W THYREL TRH AKOS015994636 Thyrotropic hormone-releasing hormone CHEMBL1472 Thyrotropin-releasing hormone DSSTox_CID_3533 TSH-RF GTPL2139 [ Show all ]
Inchi Key	XNSAINXGIQZQOO-SRVKXCTJSA-N
Inchi ID	InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
PubChem CID	638678
ChEMBL	CHEMBL1472
IUPHAR	2139
BindingDB	50072394
DrugBank	DB09421
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
396601	Thyrotropin-releasing hormone receptor	Q01717	Trhr	Rattus norvegicus (Rat)	412
396602	Thyrotropin-releasing hormone receptor	P21761	Trhr	Mus musculus (Mouse)	393
396603	Thyrotropin-releasing hormone receptor	P34981	TRHR	Homo sapiens (Human)	398

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