You can:
Name | Thyrotropin-releasing hormone receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | TRHR |
Synonym | Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor |
Disease | Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders [ Show all ] |
Length | 398 |
Amino acid sequence | MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS |
UniProt | P34981 |
Protein Data Bank | N/A |
GPCR-HGmod model | P34981 |
3D structure model | This predicted structure model is from GPCR-EXP P34981. |
BioLiP | N/A |
Therapeutic Target Database | T77796 |
ChEMBL | CHEMBL1810 |
IUPHAR | 363 |
DrugBank | BE0008659 |
Name | protirelin |
---|---|
Molecular formula | C16H22N6O4 |
IUPAC name | (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
Molecular weight | 362.39 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 4 |
XlogP | -2.5 |
Synonyms | Synthetic TRF 9015-91-2 Thyroid-stimulating hormone-releasing factor C03958 Thyrotropic-releasing factor [ Show all ] |
Inchi Key | XNSAINXGIQZQOO-SRVKXCTJSA-N |
Inchi ID | InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1 |
PubChem CID | 638678 |
ChEMBL | CHEMBL1472 |
IUPHAR | 2139 |
BindingDB | 50072394 |
DrugBank | DB09421 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
EC50 | 3.0 nM | PMID17035026 | BindingDB,ChEMBL |
Ki | 20.0 nM | PMID17035026 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417